Chanas A C, Gould E A, Clegg J C, Varma M G
J Gen Virol. 1982 Jan;58 Pt 1:37-46. doi: 10.1099/0022-1317-58-1-37.
Two monoclonal antibodies raised against Sindbis virus were shown to be specific for the envelope glycoprotein E1 by radioimmunoprecipitation (RIP). They had a number of contrasting biological properties. One of them was capable of neutralizing virus infectivity and inhibiting haemagglutination, while the other had no significant neutralizing or haemagglutination-inhibiting capability, but did inhibit virus-mediated haemolysis. Both monoclonal antibodies could enhance virus infectivity of Fc receptor-bearing macrophage-like cells when present at suitable dilutions.
通过放射免疫沉淀法（RIP）显示，两种针对辛德毕斯病毒产生的单克隆抗体对包膜糖蛋白E1具有特异性。它们具有许多截然不同的生物学特性。其中一种能够中和病毒感染性并抑制血凝，而另一种则没有明显的中和或血凝抑制能力，但确实能抑制病毒介导的溶血。当以适当的稀释度存在时，两种单克隆抗体都能增强带有Fc受体的巨噬细胞样细胞的病毒感染性。
