Dinnits E D, Kurduban L I, Finkinshteĭn Ia D
Zh Evol Biokhim Fiziol. 1977 Mar-Apr;13(2):167-72.
In experiments on puppies ageing from 3 days up to 8 months, as well as on adult dogs, studies have been made of mechanisms of excretion of water and sodium during the increase of osmotic concentration in the blood circulation of the liver and spleen. It was found that in contrast to adult dogs, in which the osmotic shift decreases diuresis and increases sodium excretion, the decrease of diuresis in 1-month puppies is accompanied by a decrease of sodium excretion. Two-component osmoregulatory reaction is developed only to the 2nd month of life. Pituitrin P, injected intravenously, evoked the same reactions which were observed in osmoregulatory reflexes at various stages of ontogenesis. Studies on papillary-cortical osmotic and sodium gradients implies that kidney reactions to osmotic shifts are realized via neurohypophysial hormones; maturation of mechanisms realizing the osmotic papillary-cortical gradient takes place previously to those which realize sodium concentration gradient.
在对3天大至8个月大的幼犬以及成年犬进行的实验中，研究了肝脏和脾脏血液循环中渗透压浓度升高时水和钠的排泄机制。结果发现，与成年犬不同，成年犬中渗透压变化会减少利尿并增加钠排泄，而1个月大的幼犬利尿减少时钠排泄也会减少。双组分渗透调节反应直到出生后第2个月才发育完全。静脉注射垂体后叶素P会引发与个体发育各阶段渗透调节反射中观察到的相同反应。对乳头体 - 皮质渗透压和钠梯度的研究表明，肾脏对渗透压变化的反应是通过神经垂体激素实现的；实现渗透压乳头体 - 皮质梯度的机制成熟先于实现钠浓度梯度的机制。
