Zabello I N, Kurduban L I, Finkinshteĭn Ia D
Zh Evol Biokhim Fiziol. 1982 Sep-Oct;18(5):477-81.
In experiments on puppies ageing from 7 days to 8 months, as well as on adult dogs, studies have been made on reflex mechanisms of potassium excretion after injection of 135 mM KCl solution (0.7 ml/kg) to the portal vein. It was found that reflex regulation of potassium extrusion undergoes 3 developmental stages: in puppies up to 1 month potassium excretion is absent; from 1 to 4 months ionuresis is not differentiated, since injection of KCl increases excretion of both K and Na; after 4 months of postnatal life potassium excretion attains its final form. Intravenous injections of pituitrin P reproduce the reactions which were observed in reflex potassium regulation in puppies up to 4 months, this finding indicating possible participation of neurohypophysial hormones in these reactions. In acute experiments it was shown that in puppies of the first month, the liver is not capable of potassium retention. This may be one of the causes of absence of reflex potassium excretion in animals of this age.
在对7日龄至8月龄幼犬以及成年犬进行的实验中，研究人员向门静脉注射135毫摩尔氯化钾溶液（0.7毫升/千克）后，对钾排泄的反射机制进行了研究。结果发现，钾排出的反射调节经历3个发育阶段：1月龄以内的幼犬不存在钾排泄；1至4月龄时离子尿症未分化，因为注射氯化钾会增加钾和钠的排泄；出生后4个月后钾排泄达到最终形式。静脉注射垂体后叶素P可重现4月龄以内幼犬反射性钾调节中观察到的反应，这一发现表明神经垂体激素可能参与了这些反应。急性实验表明，1月龄幼犬的肝脏无钾潴留能力。这可能是该年龄段动物缺乏反射性钾排泄的原因之一。
