Natural and synthetic analogues of melatonin and related compounds. I. Effects on the reproductive system of the male Syrian hamster.

The potential antigonadotrophic properties of a number of synthetic and natural melatonin analogues were examined. Adult male hamsters received daily subcutaneous injections (25 micrograms/animal/day) each afternoon for 7 or 10 weeks. The only analogue to possess antigonadotrophic activity similar to melatonin wa 6-chloromelatonin; melatonin and 6-chloromelatonin produced a significant reduction in both testicular and accessory sex organ weights, plasma LH and pituitary prolactin. These results suggest that, in the Syrian hamster, 6-chloromelatonin acts as a melatonin agonist and may be of use to elucidate further the physiological role of melatonin.