Cerklewski F L
J Nutr. 1983 Jul;113(7):1443-7. doi: 10.1093/jn/113.7.1443.
Diets containing 150 or 600 ppm magnesium with or without 200 ppm lead were fed to rats throughout gestation and lactation to determine the influence of moderate magnesium deficiency on tissue lead content of maternal and offspring tissue. During lactation it was necessary to increase the lowest dietary magnesium level to 225 ppm. Lead caused a significant depression in both gestational weight gain and average pup weight regardless of the level of dietary magnesium. Maternal magnesium deficiency was evidenced by significant reductions in serum and tibia magnesium, a 17-fold increase in kidney calcium, and hyperemia of the ears. In offspring, however, only growth and tibia magnesium were significantly affected by the magnesium deficiency, and the maternal-fetal difference in serum and tibia magnesium concentration was maintained. Maternal magnesium deficiency resulted in significantly higher lead concentrations in dam liver, and offspring erythrocytes, liver and tibia. A mechanism for the enhanced accumulation of lead in maternal and offspring tissue as a result of maternal magnesium deficiency is not defined, but it is likely to involve enhanced intestinal lead absorption.
在整个妊娠期和哺乳期，给大鼠喂食含150或600 ppm镁（含或不含200 ppm铅）的饮食，以确定中度镁缺乏对母体和后代组织中铅含量的影响。在哺乳期，有必要将最低饮食镁水平提高到225 ppm。无论饮食镁水平如何，铅都会导致妊娠期体重增加和平均幼崽体重显著下降。母体镁缺乏表现为血清和胫骨镁显著降低、肾脏钙增加17倍以及耳部充血。然而，在后代中，只有生长和胫骨镁受到镁缺乏的显著影响，并且母体和胎儿血清及胫骨镁浓度的差异得以维持。母体镁缺乏导致母体肝脏、后代红细胞、肝脏和胫骨中的铅浓度显著升高。母体镁缺乏导致母体和后代组织中铅积累增加的机制尚不清楚，但可能涉及肠道铅吸收增加。
