Tucker M A, Greene M H, Clark W H, Kraemer K H, Fraser M C, Elder D E
J Pediatr. 1983 Jul;103(1):65-9. doi: 10.1016/s0022-3476(83)80777-x.
Four prepubertal children, all members of melanoma-prone families, developed pigmented scalp lesions that were diagnosed as dysplastic nevi. In three cases, the scalp lesions were the only evidence that the children were affected by the dysplastic nevus syndrome, a distinctive clinicopathologic entity that identifies persons at increased risk of malignant melanoma. In general, the skin of family members with dysplastic nevus syndrome does not show characteristic lesions until just prior to or with the onset of puberty. The presence of dysplastic nevi on the scalp may permit identification of at least some high-risk family members well prior to puberty. This should facilitate the early implementation of a melanoma prevention program for susceptible individuals and help ensure that melanomas are diagnosed early in their natural history, at a time when they are surgically curable.
四名青春期前儿童，均为易患黑色素瘤家族的成员，出现了头皮色素沉着病变，被诊断为发育异常痣。在三例中，头皮病变是这些儿童患有发育异常痣综合征的唯一证据，发育异常痣综合征是一种独特的临床病理实体，可识别出患恶性黑色素瘤风险增加的人群。一般来说，患有发育异常痣综合征的家庭成员的皮肤在青春期前或青春期开始时才会出现特征性病变。头皮上出现发育异常痣可能有助于在青春期前很早就识别出至少一些高危家庭成员。这应有助于针对易感个体尽早实施黑色素瘤预防计划，并有助于确保在黑色素瘤处于自然病程早期、可通过手术治愈时就作出诊断。
