Stefanini M, Urbas J V, Urbas J E
Angiology. 1978 Jul;29(7):520-33. doi: 10.1177/000331977802900703.
The syndrome of plethora without splenomegaly, leukocytosis, or thrombocytosis was described by Gaisböck in 1905. It was reevaluated in 25 patients through the study of numerous hematologic and biochemical parameters. Statistically significant findings included mild obesity; elevation of blood pressure (especially diastolic); decrease in plasma volume with relative increase in red cell count, hemoglobin, hematocrit, viscosity of blood, elevation of plasma proteins, serum cholesterol, triglycerides, uric acid, and plasma renin; and increased excretion of urinary sodium. The reduction in plasma volume seemed related to the elevation of the diastolic blood pressure, and favorable through temporary therapeutic results were produced by some antihypertensive agents. The elevation of serum cholesterol, triglycerides, and uric acid, the increased blood viscosity, and the elevated plasma renin were reminescent of the biochemical changes observed in some instances of hypertension and atherosclerotic disease. They may explain why patients with the Gaisböck's syndrome belong to the high risk group of hypertensive individuals who often develop cardiovascular complications. While its long-term effects remain to be evaluated, treatment with nondiuretic antihypertensive drugs may help reduce the incidence of these complications.
盖斯伯克于1905年描述了无脾肿大、白细胞增多或血小板增多的多血症综合征。通过对众多血液学和生化参数的研究，对25例患者进行了重新评估。具有统计学意义的发现包括轻度肥胖；血压升高（尤其是舒张压）；血浆量减少，红细胞计数、血红蛋白、血细胞比容、血液粘度相对增加，血浆蛋白、血清胆固醇、甘油三酯、尿酸和血浆肾素升高；以及尿钠排泄增加。血浆量的减少似乎与舒张压升高有关，一些抗高血压药物产生了暂时的治疗效果。血清胆固醇、甘油三酯和尿酸的升高、血液粘度的增加以及血浆肾素的升高让人想起在某些高血压和动脉粥样硬化疾病中观察到的生化变化。这可能解释了为什么患有盖斯伯克综合征的患者属于经常发生心血管并发症的高血压高危人群。虽然其长期影响仍有待评估，但使用非利尿性抗高血压药物进行治疗可能有助于降低这些并发症的发生率。
