Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases and Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Pflugers Arch. 2011 Feb;461(2):211-23. doi: 10.1007/s00424-010-0902-5. Epub 2010 Nov 26.
The transient receptor potential (TRP) channel superfamily is composed of 28 nonselective cation channels that are ubiquitously expressed in many cell types and have considerable functional diversity. Although changes in TRP channel expression and function have been reported in cardiovascular disease and renal disorders, the pathogenic roles of TRP channels in metabolic diseases have not been systemically reviewed. In this review, we summarised the distribution of TRP channels in several metabolic tissues and discussed their roles in mediating and regulating various physiological and pathophysiological metabolic processes and diseases including diabetes, obesity, dyslipidaemia, metabolic syndrome, atherosclerosis, metabolic bone diseases and electrolyte disturbances. This review provides new insight into the involvement of TRP channels in the pathogenesis of metabolic disorders and implicates these channels as potential therapeutic targets for the management of metabolic diseases.
瞬时受体电位 (TRP) 通道超家族由 28 种非选择性阳离子通道组成，广泛表达于多种细胞类型中，具有相当大的功能多样性。尽管 TRP 通道表达和功能的改变已在心血管疾病和肾脏疾病中被报道，但 TRP 通道在代谢性疾病中的致病作用尚未被系统地综述。在这篇综述中，我们总结了 TRP 通道在几种代谢组织中的分布，并讨论了它们在介导和调节各种生理和病理生理代谢过程和疾病中的作用，包括糖尿病、肥胖症、血脂异常、代谢综合征、动脉粥样硬化、代谢性骨病和电解质紊乱。这篇综述为 TRP 通道参与代谢紊乱的发病机制提供了新的见解，并暗示这些通道可能成为代谢性疾病治疗的潜在靶点。
