Rodriguez M, von Wedel R J, Garrett R S, Lampert P W, Oldstone M B
Lab Invest. 1983 Jul;49(1):48-53.
Most strains of mice injected intracerebrally with lymphocytic choriomeningitis virus grow to adulthood maintaining a persistent virus infection associated with chronic virus-induced immune complex disease. However, mice on a k background are highly susceptible to neonatal infection and develop the clinical syndrome of pituitary dwarfism and hypoglycemia. Examination of pituitary tissue fails to reveal morphologic alteration by light and electron microscopy. Within the pituitary, viral antigens are exclusively distributed within the cells of the adenohypophysis. Using ultrastructural colloidal gold-labeling techniques, we demonstrate the presence of mature virus particles budding from the surface of growth hormone containing cells from the pituitary. This study indicates that persistent lymphocytic choriomeningitis virus infection of the growth hormone cells in susceptible mice is associated with pituitary dwarfism without producing visible structural damage.
大多数经脑内注射淋巴细胞性脉络丛脑膜炎病毒的小鼠品系能够存活至成年，维持一种与慢性病毒诱导的免疫复合物疾病相关的持续性病毒感染。然而，k背景的小鼠对新生儿感染高度易感，并会发展出垂体性侏儒症和低血糖的临床综合征。对垂体组织进行检查，通过光学显微镜和电子显微镜均未发现形态学改变。在垂体内，病毒抗原仅分布于腺垂体细胞内。利用超微结构胶体金标记技术，我们证明了在垂体中含生长激素的细胞表面有成熟病毒颗粒出芽。这项研究表明，易感小鼠生长激素细胞的持续性淋巴细胞性脉络丛脑膜炎病毒感染与垂体性侏儒症相关，且未产生明显的结构损伤。
