Rosenberg L, Brown R A, Duguid W P
J Surg Res. 1983 Jul;35(1):63-72. doi: 10.1016/0022-4804(83)90127-0.
There is ample evidence that a relationship exists between duct epithelial hyperplasia and carcinoma of the pancreas. However, no experimental system exists to investigate the mechanisms involved. A new model is described in the Syrian golden hamster for inducing duct epithelial hyperplasia and nesidioblastosis. The head of the pancreas is wrapped with cellophane tape; ligation of the duct is not involved and there is no evidence of diffuse pancreatitis. Preliminary studies have revealed that this model results in periductal fibrosis in relation to the cellophane thus producing partial duct obstruction. Concomitant with the fibrosis there is duct epithelial hyperplasia in the head of the gland, while peripherally there is ductular proliferation and the initiation of nesidioblastosis. It is believed that this model will be of use in studies of pancreatic carcinogenesis and will thus enhance our knowledge of the interrelationships between etiologic factors, precursor lesions, and pancreatic cancer. This is of particular importance in the early recognition of this neoplasm in man.
有充分证据表明胰腺导管上皮增生与胰腺癌之间存在关联。然而，目前尚无用于研究其中所涉及机制的实验系统。本文描述了一种在叙利亚金黄地鼠中诱导导管上皮增生和胰岛母细胞增殖的新模型。用玻璃纸胶带包裹胰腺头部；不涉及导管结扎，且无弥漫性胰腺炎的证据。初步研究表明，该模型会导致与玻璃纸相关的导管周围纤维化，从而造成部分导管梗阻。与纤维化同时出现的是腺头部的导管上皮增生，而在周边则有小导管增生和胰岛母细胞增殖的起始。据信，该模型将有助于胰腺癌发生机制的研究，从而增进我们对病因学因素、前驱病变和胰腺癌之间相互关系的了解。这对于人类早期识别这种肿瘤尤为重要。
