Rosenberg L, Duguid W P, Brown R A
Am J Surg. 1984 Jan;147(1):146-51. doi: 10.1016/0002-9610(84)90049-7.
The majority of carcinomas of the pancreas in humans are of ductal origin and are located in the head of the gland. These clinical characteristics however, are not affected in traditional animal models of the disease. Partial pancreatic duct obstruction with ductal epithelial hyperplasia was produced in the Syrian golden hamster by wrapping the head of the pancreas with cellophane tape. Wrapped and unwrapped animals were then exposed to an exogenous carcinogen (N-nitrosobis[2-oxopropyl]amine). Assay of serum ribonuclease activity was used as a marker of disease. Invasive lesions developed in both groups of animals. Fifty percent of the tumors in the Group II (cellophane wrap and N-nitrosobis [2-oxopropyl] amine) hamsters were located in the head of the gland and were of ductal origin. All tumors in animals receiving N-nitrosobis [2-oxopropyl]amine alone (Group I) occurred peripherally and were derived from ductular or acinar tissue. Elevation of serum ribonuclease activity was noted early in the course of carcinogenesis, thereafter returning to normal, which may explain the clinical controversy regarding this marker. This new model should enhance our knowledge of the interrelationships between etiologic factors, precursor lesions, and pancreatic cancer.
人类大多数胰腺癌起源于导管，位于胰腺头部。然而，这些临床特征在该疾病的传统动物模型中并未受到影响。通过用玻璃纸胶带包裹叙利亚金仓鼠的胰腺头部，造成部分胰腺导管阻塞并伴有导管上皮增生。然后，对包裹和未包裹的动物施加外源性致癌物（N-亚硝基双[2-氧代丙基]胺）。血清核糖核酸酶活性测定用作疾病标志物。两组动物均出现侵袭性病变。在第二组（玻璃纸包裹加N-亚硝基双[2-氧代丙基]胺）仓鼠中，50%的肿瘤位于胰腺头部，起源于导管。仅接受N-亚硝基双[2-氧代丙基]胺的动物（第一组）中的所有肿瘤均发生在周边，源自小导管或腺泡组织。血清核糖核酸酶活性在致癌过程早期升高，随后恢复正常，这可能解释了关于该标志物的临床争议。这个新模型应该会增进我们对病因学因素、前驱病变和胰腺癌之间相互关系的了解。
