Gelb R I, Schwartz L M, Laufer D A
Life Sci. 1983 Jul 4;33(1):83-5. doi: 10.1016/0024-3205(83)90714-2.
Spectrophotometric and pH potentiometric studies indicate that cyclohexaamylose (alpha-cyclodextrin) and cycloheptaamylose (beta-cyclodextrin) form aqueous complexes with all adamantane derivatives examined to date. Thermodynamic complex formation constants are reported for the substrates 1-adamantaneamine (amantadine), 1-adamantaneammonium ion, 1-adamantanemethylamine, 1-adamantane-methylammonium ion, 1-adamantanecarboxylic acid, 1-adamantane-carboxylate ion, 1-adamantaneacetic acid and 1-adamantaneacetate ion. The existence of these complexes implies that cycloamylose might serve as a therapeutic sequestering agent for adamantane derivatives.
分光光度法和pH电位滴定法研究表明，环六糊精（α-环糊精）和环七糊精（β-环糊精）与迄今所检测的所有金刚烷衍生物形成水相配合物。报道了底物1-金刚烷胺（金刚烷胺）、1-金刚烷铵离子、1-金刚烷甲胺、1-金刚烷甲基铵离子、1-金刚烷羧酸、1-金刚烷羧酸盐离子、1-金刚烷乙酸和1-金刚烷乙酸盐离子的热力学配合物形成常数。这些配合物的存在意味着环糊精可能作为金刚烷衍生物的治疗性螯合剂。
