Wong A B, Lin S F, Connors K A
J Pharm Sci. 1983 Apr;72(4):388-90. doi: 10.1002/jps.2600720417.
Complex formation of alpha-cyclodextrin with 15 amines (including seven 4-substituted anilines) was studied by the potentiometric method, supplemented by direct UV spectrophotometry and a competitive indicator spectrophotometric method. The data were analyzed in terms of 1:1 and 1:2 complexes (amine-cyclodextrin ratios) and the stability constants K11a, K12a, K11b, and K12b were evaluated; the subscripts indicate the stoichiometry and conjugate acid-base form. For all amines K11b was greater than K11a and K12a was 0. On the basis of the relationship of complex stability to amine structure, it was concluded that the primary binding site in anilines is the 4-substituent.
采用电位滴定法，并辅以直接紫外分光光度法和竞争指示剂分光光度法，研究了α-环糊精与15种胺（包括7种4-取代苯胺）的络合物形成情况。根据1:1和1:2络合物（胺与环糊精的比例）对数据进行分析，并评估了稳定常数K11a、K12a、K11b和K12b；下标表示化学计量比和共轭酸碱形式。对于所有胺类，K11b大于K11a，且K12a为0。根据络合物稳定性与胺结构的关系，得出苯胺中的主要结合位点是4-取代基。
