BB 系Wistar大鼠：一种用于研究糖尿病视网膜病变的实验模型。
The BB Wistar rat: an experimental model for the study of diabetic retinopathy.
作者信息
Sima A A, Garcia-Salinas R, Basu P K
出版信息
Metabolism. 1983 Jul;32(7 Suppl 1):136-40. doi: 10.1016/s0026-0495(83)80027-4.
Diabetic retinopathy was studied in the spontaneously diabetic BB Wistar rat with respect to qualitative and quantitative structural changes. Trypsin-digested retinal preparations revealed after 8 to 11 months of diabetes a decrease in the pericyte/endothelial cell ratio. Quantitative ultrastructural examinations showed no increase in the vascularity or in basement-membrane thickness in diabetic animals. However, retinal capillaries showed not infrequently occlusions by fibrin and platelet thrombi.
对自发性糖尿病BB Wistar大鼠的糖尿病视网膜病变进行了定性和定量结构变化方面的研究。经胰蛋白酶消化的视网膜标本显示，糖尿病8至11个月后周细胞/内皮细胞比例降低。定量超微结构检查显示，糖尿病动物的血管密度或基底膜厚度没有增加。然而，视网膜毛细血管经常出现纤维蛋白和血小板血栓阻塞。
Zotero 插件