原核生物基因组DNA抑制哺乳动物细胞转化。
Procaryotic genomic DNA inhibits mammalian cell transformation.
作者信息
Yoder J I, Ganesan A T
出版信息
Mol Cell Biol. 1983 May;3(5):956-9. doi: 10.1128/mcb.3.5.956-959.1983.
Abstract
Ltk- mouse cells were transformed to thymidine kinase prototrophy in the presence of carrier DNAs isolated from different organisms. Procaryotic genomic and phage DNA was consistently less effective as a carrier than was eucaryotic DNA. Mixing experiments indicate that DNA of procaryotic origin inhibits mammalian cell transformation.
摘要
在存在从不同生物体分离的载体DNA的情况下，Ltk-小鼠细胞被转化为胸苷激酶原养型。原核基因组DNA和噬菌体DNA作为载体的效果始终不如真核DNA。混合实验表明，原核来源的DNA会抑制哺乳动物细胞的转化。
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