Hürzeler D
Ann Otol Rhinol Laryngol. 1978 Jul-Aug;87(4 Pt 1):528-32. doi: 10.1177/000348947808700412.
The still unsatisfactory prognosis of bronchogenic carcinoma prompted the search for possibilities of better early and detailed diagnosis. This led us to the idea of UV-fluorescence bronchoscopy. The patient inhales 5 ml of an aqueous 5% solution of fluorescein, together with a beta2 stimulator, 10-15 minutes before the bronchoscopy, by means of a pressure inhaler. While the normal mucous membrane cleanses itself by virtue of ciliary action (secretions containing fluorescein are expectorated or drawn off during the bronchoscopy), carcinoma, carcinomatous lymphangiosis, superficial tumor infiltrations and nonciliated metaplasias are stained. These places fluoresce in UV light, even when they cannot be observed with the naked eye or with an optical system. In this way, they are made visible for directed biospy. Malignant changes not discernible by means of the methods hitherto employed can thus be diagnosed and sites determined with greater accuracy for proposed resection.
支气管源性癌的预后仍不尽人意，这促使人们探寻更好的早期及详细诊断方法。这使我们萌生了紫外线荧光支气管镜检查的想法。在支气管镜检查前10 - 15分钟，患者通过压力吸入器吸入5毫升5%的荧光素水溶液以及一种β2激动剂。正常黏膜凭借纤毛运动自行清洁（含荧光素的分泌物在支气管镜检查期间被咳出或吸出），而癌、癌性淋巴管炎、浅表肿瘤浸润和无纤毛化生则会被染色。这些部位在紫外线下会发出荧光，即便用肉眼或光学系统无法观察到。通过这种方式，它们对于定向活检变得可见。因此，借助迄今所采用的方法无法辨别的恶性病变能够得以诊断，并且对于拟行切除的部位能够更准确地确定。
