Homasson J P, Bonniot J P, Angebault M, Renault P, Carnot F, Santelli G
Thorax. 1985 Jan;40(1):38-40. doi: 10.1136/thx.40.1.38.
The presence of fluorescence was assessed in 34 unselected patients undergoing bronchoscopy, 11 of whom suffered from bronchial carcinoma. Bronchoscopic inspection was carried out with white light and then repeated with blue light after the injection of 2 ml of 10% sodium fluoresceinate. Fluorescence was graded visually. Seventy six pairs of biopsy specimens were obtained. Of 38 specimens from non fluorescent areas, histological appearances were normal in 34. Slight inflammation was observed in three biopsy specimens, and in one there was evidence of tumour even though the specimen was obtained some distance from the primary tumour. Of 38 biopsy specimens from fluorescent areas, histological examination showed appearances of moderate inflammation in 10, severe inflammation in 10, tuberculosis in one, and carcinoma in 11. In six instances histological appearances were normal. Five normal subjects who were smokers were also examined by the same technique. Appearances of metaplasia were found more often in areas showing fluorescence than in areas not showing fluorescence. Bronchial fluorescence is considered to be related to alteration in vascularity and is not specific for carcinoma. The most fluorescent areas are generally the most pathological and visible tumour is very fluorescent, but moderate degrees of fluorescence are difficult to interpret. Biopsy of every fluorescent area seems excessive.
对34例接受支气管镜检查的未经挑选的患者评估了荧光的存在情况，其中11例患有支气管癌。先用白光进行支气管镜检查，然后在注射2ml 10%荧光素钠后用蓝光重复检查。通过视觉对荧光进行分级。共获取了76对活检标本。在38份来自非荧光区域的标本中，34份的组织学表现正常。在3份活检标本中观察到轻度炎症，在1份标本中尽管取材部位距原发肿瘤有一定距离但有肿瘤证据。在38份来自荧光区域的活检标本中，组织学检查显示10份有中度炎症表现，10份有重度炎症表现，1份为结核，11份为癌。6份标本的组织学表现正常。还对5名吸烟的正常受试者采用相同技术进行了检查。化生表现更多见于显示荧光的区域而非未显示荧光的区域。支气管荧光被认为与血管改变有关，并非癌所特有。荧光最强的区域通常病理改变最明显，可见肿瘤的荧光很强，但中等程度的荧光难以解读。对每个荧光区域都进行活检似乎过于繁琐。
