Pizzey J A, Barnard E A
Neuropathol Appl Neurobiol. 1983 Mar-Apr;9(2):149-64. doi: 10.1111/j.1365-2990.1983.tb00332.x.
Dystrophic (D) and normal (N) chicken pectoral muscle was analysed for histopathological differences from the embryo (day 20) through to the mature adult stage. A variety of indices of structural changes were used, to express the progression quantitatively. At the embryonic stage, fibroblast numbers (but not satellite cell numbers) are increased in D. D shows fibre hypertrophy discernible from about 4 days after hatching. Other abnormalities of fibre size and shape appear in D from about 2 weeks onwards. Nuclei numbers and location change characteristically in D, compared to N, from about 4 days, and these differences subsequently become very prominent. Fibre splitting and phagocytosis become significant in D from about 2 weeks onwards and increase noticeably thereafter. The later stages in D, with gross loss of muscle fibres, are also described, in the pectoral and posterior latissimus dorsi muscles. The analyses show that some of the structural changes in D precede the discernible difference in fibre type composition which develops between D and N. The changes in the muscle used provide a basis for assessing the effects of drug treatments at various stages, including the early post-hatch period.
对营养不良（D）和正常（N）的鸡胸肌进行分析，观察从胚胎期（第20天）到成年期的组织病理学差异。使用了各种结构变化指标来定量表达其进展情况。在胚胎期，D组的成纤维细胞数量（而非卫星细胞数量）增加。D组在孵化后约4天可观察到纤维肥大。从大约2周起，D组出现纤维大小和形状的其他异常。与N组相比，D组的细胞核数量和位置从大约4天起出现特征性变化，且这些差异随后变得非常显著。从大约2周起，D组的纤维分裂和吞噬作用变得显著，此后明显增加。还描述了D组后期胸肌和背阔肌后部肌肉纤维大量丧失的情况。分析表明，D组的一些结构变化先于D组和N组之间在纤维类型组成上可察觉的差异。所使用肌肉的变化为评估包括孵化后早期在内的各个阶段药物治疗的效果提供了依据。
