Yu J H
Prostaglandins. 1986 Jun;31(6):1087-97. doi: 10.1016/0090-6980(86)90212-1.
Exogenously administered PGE1 or PGE2, like atropine, markedly decreased both the flow and calcium concentration of parasympathetically evoked rat parotid saliva; PGF2 alpha was less effective. Despite the fact that prostaglandins greatly reduced the Ca concentration of nerve-evoked saliva, they did not change the glandular Ca concentration of either control or parasympathetically stimulated parotid glands. Prostaglandins (20 micrograms/kg, i.a.) decreased the Na or K concentration of nerve-evoked parotid saliva, but at lower doses had no significant effect. PGE1, PGE2, PGF2 alpha or atropine markedly decreased flow rates of similarly evoked rat submandibular saliva. Prostaglandins and atropine, however, decreased the Na concentration and increased the K concentration of parasympathetically evoked submandibular saliva. PGF2 alpha, like atropine, increased the Ca concentration of such saliva. Drug vehicle, ethanol, slightly decreased the flow of both parotid and submandibular saliva but not the ion secretion, Endogenous prostaglandins themselves may not play a role in secretory activities during parasympathetic nerve stimulation of rat salivary glands, since administration of indomethacin, and inhibitor of prostaglandin biosynthesis, prior to or during nerve stimulation did not significantly alter nerve-evoked salivary secretion, The mechanisms by which prostaglandins modulate secretory responses of salivary glands during parasympathetic stimulation are not understood.
外源性给予的前列腺素E1或前列腺素E2，与阿托品一样，能显著降低副交感神经诱发的大鼠腮腺唾液的流量和钙浓度；前列腺素F2α的作用较小。尽管前列腺素能大大降低神经诱发唾液中的钙浓度，但它们并未改变对照或副交感神经刺激的腮腺的腺体钙浓度。前列腺素（20微克/千克，腹腔注射）可降低神经诱发的腮腺唾液中的钠或钾浓度，但在较低剂量时无显著影响。前列腺素E1、前列腺素E2、前列腺素F2α或阿托品可显著降低类似诱发的大鼠颌下腺唾液的流速。然而，前列腺素和阿托品可降低副交感神经诱发的颌下腺唾液中的钠浓度并增加钾浓度。前列腺素F2α与阿托品一样，可增加此类唾液中的钙浓度。药物载体乙醇可轻微降低腮腺和颌下腺唾液的流量，但不影响离子分泌。内源性前列腺素本身可能在大鼠唾液腺副交感神经刺激期间的分泌活动中不起作用，因为在神经刺激之前或期间给予前列腺素生物合成抑制剂吲哚美辛并未显著改变神经诱发的唾液分泌。目前尚不清楚前列腺素在副交感神经刺激期间调节唾液腺分泌反应的机制。
