Schrot J, Thomas J R
Pharmacol Biochem Behav. 1983 Apr;18(4):529-34. doi: 10.1016/0091-3057(83)90276-9.
The acute effects of d-amphetamine on response patterning in a repeated acquisition baseline were investigated with rats. Each session the animals acquired a different four-member response sequence on three levers. Each sequence (trial) completion produced a food pellet. Errors produced a brief timeout that was reset by responses made during the timeout. Acute doses of d-amphetamine (0.5-4.0 mg/kg) and saline were administered 30 min presession. The response patterns analyzed were perseverative responses to a single lever (runs), and a response to each lever in either a left-to-right or right-to-left direction (traverses). The trial position, frequency, and lever location of error and timeout responses that occurred in the context of runs and traverses were studied. In contrast to control sessions, higher doses of d-amphetamine produced increases in the number of error and timeout responses emitted. The majority of these responses occurred as runs; traverse responding did not exceed control levels. Furthermore, the run error and timeout responding tended to occur early in the session and on a single response lever. The results are consistent with the view that d-amphetamine disrupts stimulus control and produces perseverative responding which may account for previous reports of disruption in repeated acquisition tasks following d-amphetamine administration.
用大鼠研究了右旋苯丙胺对重复习得基线中反应模式的急性影响。在每个实验环节，动物们在三个杠杆上习得一个不同的四元反应序列。每次序列（试验）完成都会产生一粒食物丸。错误会导致短暂的超时，超时期间的反应可重置超时。在实验环节开始前30分钟给予急性剂量的右旋苯丙胺（0.5 - 4.0毫克/千克）和生理盐水。分析的反应模式包括对单个杠杆的持续性反应（连续反应），以及从左到右或从右到左方向对每个杠杆的反应（遍历反应）。研究了在连续反应和遍历反应情境中出现的错误和超时反应的试验位置、频率以及杠杆位置。与对照实验环节相比，较高剂量的右旋苯丙胺会使发出的错误和超时反应数量增加。这些反应大多以连续反应的形式出现；遍历反应未超过对照水平。此外，连续反应中的错误和超时反应往往在实验环节早期出现，且发生在单个反应杠杆上。这些结果与以下观点一致，即右旋苯丙胺会破坏刺激控制并产生持续性反应，这可能解释了先前关于右旋苯丙胺给药后重复习得任务受到干扰的报道。
