Hall N R, Luttge W G
Pharmacol Biochem Behav. 1977 Jun;6(6):677-81. doi: 10.1016/0091-3057(77)90094-6.
A group of estrogen-primed, ovariectomized rats was adrenalectomized and tested for sexual receptivity following hypothalamic implantations of PGE2. The combination of PGE2 and adrenalectomy led to severe debilitation as manifested by greatly reduced open-field activity scores and inhibition of estrogen and progesterone induced sexual receptivity. Neither exogenous progesterone nor corticosterone was able to restore these behaviors to normal levels. A mechanism involving PGE2 and adrenalectomy-induced transient ischemia was discussed as a possible cause of the debilitation.
一组经雌激素预处理的去卵巢大鼠接受肾上腺切除术，然后在下丘脑植入前列腺素E2（PGE2）后测试其性接受能力。PGE2与肾上腺切除术的联合作用导致严重虚弱，表现为旷场活动得分大幅降低以及雌激素和孕酮诱导的性接受能力受到抑制。外源性孕酮和皮质酮均无法将这些行为恢复到正常水平。讨论了一种涉及PGE2和肾上腺切除术诱导的短暂性缺血的机制，认为这可能是导致虚弱的原因。
