• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

吗啡与假定强化物的可接受性

Morphine and acceptability of putative reinforcers.

作者信息

Calcagnetti D J, Reid L D

出版信息

Pharmacol Biochem Behav. 1983 Apr;18(4):567-9. doi: 10.1016/0091-3057(83)90282-4.

DOI:10.1016/0091-3057(83)90282-4
PMID:6867062
Abstract

Rats were given the opportunity to take one of five concentrations of saccharin solutions. Intake across concentrations generated a preference-aversion curve. Morphine, 2 mg/kg, increased intake of saccharin solutions when rats were 12-hr water deprived or were not deprived. These effects with morphine are opposite to those of naloxone and strengthen the idea that there is opioid involvement in incentive motivation.

摘要

给予大鼠选择五种不同浓度糖精溶液之一的机会。不同浓度下的摄入量产生了一条偏好-厌恶曲线。当大鼠被剥夺12小时水分或未被剥夺水分时,2毫克/千克的吗啡会增加糖精溶液的摄入量。吗啡的这些作用与纳洛酮的作用相反,强化了阿片类物质参与动机激励的观点。

相似文献

1
Morphine and acceptability of putative reinforcers.吗啡与假定强化物的可接受性
Pharmacol Biochem Behav. 1983 Apr;18(4):567-9. doi: 10.1016/0091-3057(83)90282-4.
2
Modulation of saccharin preference by morphine and naloxone: inversion of drug effects as a function of saccharin concentration.吗啡和纳洛酮对糖精偏好的调节:药物效应随糖精浓度的变化而反转。
Pharmacol Biochem Behav. 1991 Jan;38(1):37-41. doi: 10.1016/0091-3057(91)90586-q.
3
Naloxone suppresses intake of highly preferred saccharin solutions in food deprived and sated rats.
Life Sci. 1983 Nov 7;33(19):1909-14. doi: 10.1016/0024-3205(83)90675-6.
4
Intake of and preference for sweet solutions are attenuated in morphine-withdrawn rats.吗啡戒断的大鼠对甜味溶液的摄取和偏好会减弱。
Behav Neurosci. 1991 Dec;105(6):965-70. doi: 10.1037//0735-7044.105.6.965.
5
Ibotenic acid lesion of the lateral hypothalamus increases preference and aversion thresholds for saccharin and alters the morphine modulation of taste.
Pharmacol Biochem Behav. 1990 Jul;36(3):585-91. doi: 10.1016/0091-3057(90)90259-k.
6
Antagonism of morphine-induced aversive conditioning by naloxone.纳洛酮对吗啡诱导的厌恶条件反射的拮抗作用。
Pharmacol Biochem Behav. 1975 Mar-Apr;3(2):185-8. doi: 10.1016/0091-3057(75)90146-x.
7
Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake.长期摄入高剂量糖精诱导的基因选择大鼠的吗啡耐受性。
Science. 1983 Aug 26;221(4613):871-3. doi: 10.1126/science.6879185.
8
Morphine and naloxone modulate intake of ethanol.吗啡和纳洛酮调节乙醇摄入量。
Alcohol. 1984 Jan-Feb;1(1):33-7. doi: 10.1016/0741-8329(84)90033-8.
9
Drug reinforcement studied by the use of place conditioning in rat.通过在大鼠中使用位置条件反射来研究药物强化作用。
Brain Res. 1982 Jul 8;243(1):91-105. doi: 10.1016/0006-8993(82)91123-4.
10
Beyond sweet taste: saccharin, sucrose, and polycose differ in their effects upon morphine-induced analgesia.超越甜味:糖精、蔗糖和多糖对吗啡诱导的镇痛作用存在差异。
Pharmacol Biochem Behav. 1997 Mar;56(3):341-5. doi: 10.1016/s0091-3057(96)00227-4.

引用本文的文献

1
Intact Hedonic Responses to Sweet Tastes in Autism Spectrum Disorder.自闭症谱系障碍患者对甜味的享乐反应完整无缺。
Res Autism Spectr Disord. 2014 Mar;8(3):230-236. doi: 10.1016/j.rasd.2013.12.003.
2
Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.新型μ阿片受体拮抗剂对暴食肥胖人群的神经和行为影响。
Biol Psychiatry. 2013 May 1;73(9):887-94. doi: 10.1016/j.biopsych.2012.10.022. Epub 2012 Dec 14.
3
Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence.
甜味喜好表型、酒精渴求与酒精依赖患者对纳曲酮治疗的反应。
Alcohol Alcohol. 2009 May-Jun;44(3):293-300. doi: 10.1093/alcalc/agn122. Epub 2009 Feb 3.
4
Activation of delta-opioid receptors reduces excitatory input to putative gustatory cells within the nucleus of the solitary tract.δ-阿片受体的激活减少了孤束核内假定味觉细胞的兴奋性输入。
J Neurophysiol. 2009 Jan;101(1):258-68. doi: 10.1152/jn.90648.2008. Epub 2008 Nov 19.
5
Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus.食物剥夺会增加腹内侧下丘脑和弓状核中微阿片受体的mRNA表达。
Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1385-90. doi: 10.1152/ajpregu.00030.2008. Epub 2008 Sep 3.
6
Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food.在脑桥臂旁核中对μ-阿片受体(MOR)G蛋白偶联进行长期抑制,会持续减少标准食物的摄入量,但不会减少美味食物的摄入量。
Psychopharmacology (Berl). 2006 Sep;187(4):435-46. doi: 10.1007/s00213-006-0463-7. Epub 2006 Jul 18.
7
Female preproenkephalin-knockout mice display altered emotional responses.雌性前脑啡肽原基因敲除小鼠表现出情绪反应改变。
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1958-63. doi: 10.1073/pnas.98.4.1958. Epub 2001 Feb 6.
8
Effects of a selective mu opioid receptor agonist and naloxone on the intake of sodium chloride solutions.一种选择性μ阿片受体激动剂和纳洛酮对氯化钠溶液摄入量的影响。
Psychopharmacology (Berl). 1990;100(1):66-71. doi: 10.1007/BF02245792.