Ettenberg A, Le Moal M, Koob G F, Bloom F E
Pharmacol Biochem Behav. 1983 Apr;18(4):645-7. doi: 10.1016/0091-3057(83)90294-0.
Rats were tested in a simple one-trial water-finding task for the effects of arginine vasopressin (AVP) on performance of an appetitive task. On the training day, each animal was exposed for 5 min to a novel open-field environment that contained a water-tube located in an alcove set into one of the walls of the enclosure. Immediately upon removal from the enclosure, the animals received a subcutaneous injection of either AVP (1 microgram/rat) or vehicle solution. When water-deprived and tested 48 hr later, vasopressin-treated rats found the water tube reliably faster than controls. In other groups of animals, this potentiation in learned performance was prevented by concurrently treating the rats with a vasopressin analog having potent pressor antagonist properties. These results are consistent with the notion that vasopressin may play a role in memory consolidation, but peripheral visceral factors may mediate this action.
在一项简单的一次性水寻找任务中，对大鼠进行了精氨酸加压素（AVP）对一项欲求性任务表现影响的测试。在训练日，将每只动物置于一个新的旷场环境中5分钟，该环境中有一根水管，位于围场一面墙凹处的壁龛内。从围场取出后，动物立即接受皮下注射AVP（1微克/大鼠）或赋形剂溶液。当48小时后对缺水的大鼠进行测试时，接受加压素治疗的大鼠找到水管的速度确实比对照组快。在其他几组动物中，通过同时给大鼠使用具有强力升压拮抗特性的加压素类似物，可防止学习表现的这种增强。这些结果与加压素可能在记忆巩固中起作用的观点一致，但外周内脏因素可能介导了这一作用。
