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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nishida N, Katamine S, Shigematsu K, Nakatani A, Sakamoto N, Hasegawa S, Nakaoke R, Atarashi R, Kataoka Y, Miyamoto T

Department of Bacteriology, Nagasaki University School of Medicine, Japan.

Cell Mol Neurobiol. 1997 Oct;17(5):537-45. doi: 10.1023/a:1026315006619.

The cellular prion protein, designated PrPc, is a key molecule in the prion diseases but its physiological function remains unknown. To elucidate whether PrPc plays some role in the central nervous system, we established a line of mice in which the PrP gene had been disrupted and subsequently conducted long-term observations. 2. Performance in latent learning and passive avoidance was evaluated using water-finding and step-through tests, respectively. 3. PrP-/- mice showed impaired performance in the water-finding test, indicating a disturbance in latent learning, at 23 weeks of age. In the step-through test, although the PrP-/- mice showed normal learning ability and short-term memory retention, they evidenced a significant disturbance in long-term memory retention. 4. These results indicate that PrPc is needed for certain types of learning and memory and that the loss of function of this protein may contribute to the pathogenesis of prion diseases.

细胞朊蛋白，称为PrPc，是朊病毒疾病中的关键分子，但其生理功能仍不清楚。为了阐明PrPc是否在中枢神经系统中发挥某种作用，我们建立了一个PrP基因已被破坏的小鼠品系，并随后进行了长期观察。2. 分别使用找水试验和穿梭试验评估潜在学习和被动回避的表现。3. PrP-/-小鼠在23周龄时在找水试验中表现受损，表明潜在学习受到干扰。在穿梭试验中，虽然PrP-/-小鼠表现出正常的学习能力和短期记忆保持，但它们在长期记忆保持方面明显受到干扰。4. 这些结果表明，PrPc是某些类型的学习和记忆所必需的，并且这种蛋白质的功能丧失可能导致朊病毒疾病的发病机制。

Nishida N, Katamine S, Shigematsu K, Nakatani A, Sakamoto N, Hasegawa S, Nakaoke R, Atarashi R, Kataoka Y, Miyamoto T

Department of Bacteriology, Nagasaki University School of Medicine, Japan.

Cell Mol Neurobiol. 1997 Oct;17(5):537-45. doi: 10.1023/a:1026315006619.

The cellular prion protein, designated PrPc, is a key molecule in the prion diseases but its physiological function remains unknown. To elucidate whether PrPc plays some role in the central nervous system, we established a line of mice in which the PrP gene had been disrupted and subsequently conducted long-term observations. 2. Performance in latent learning and passive avoidance was evaluated using water-finding and step-through tests, respectively. 3. PrP-/- mice showed impaired performance in the water-finding test, indicating a disturbance in latent learning, at 23 weeks of age. In the step-through test, although the PrP-/- mice showed normal learning ability and short-term memory retention, they evidenced a significant disturbance in long-term memory retention. 4. These results indicate that PrPc is needed for certain types of learning and memory and that the loss of function of this protein may contribute to the pathogenesis of prion diseases.

细胞朊蛋白，称为PrPc，是朊病毒疾病中的关键分子，但其生理功能仍不清楚。为了阐明PrPc是否在中枢神经系统中发挥某种作用，我们建立了一个PrP基因已被破坏的小鼠品系，并随后进行了长期观察。2. 分别使用找水试验和穿梭试验评估潜在学习和被动回避的表现。3. PrP-/-小鼠在23周龄时在找水试验中表现受损，表明潜在学习受到干扰。在穿梭试验中，虽然PrP-/-小鼠表现出正常的学习能力和短期记忆保持，但它们在长期记忆保持方面明显受到干扰。4. 这些结果表明，PrPc是某些类型的学习和记忆所必需的，并且这种蛋白质的功能丧失可能导致朊病毒疾病的发病机制。