Augustin M, Berceanu-Gabrielescu A, Ioaniţiu D, Dumitrache M, Marinescu I, Mănciulescu D, Ciocîrdia C, Tache A, Cristoveanu A, Bunea M, Dimitriu V, Dinulescu E
Endocrinologie. 1983 Apr-Jun;21(2):123-9.
The investigation was carried out on 66 patients with hypo- or hyperfunctional syndromes of adrenocorticism, hospitalized and treated by our team. The patients were grouped into 5 lots according to their diseases. Lot one consisted of 34 female patients with Cushing's syndrome, lot two of 10 males with Cushing's syndrome, lot three of 10 males with Addison's disease and lot four, of 6 females with androgenic hypercorticism. The morphofunctional disorders of reproduction were followed up clinically and by complex hormone assays, before and after treatment. The incidence of these disorders is very high, and the results of clinical observations and of laboratory data demonstrate that both the excess of adrenocortical hormones and the decrease in their circulating level have a negative influence on the reproduction function or represent a risk factor in cases of pregnancy. By the curative treatment of the adrenal cortex a preventive treatment of abortion and/or sterility is achieved.
我们团队对66例肾上腺皮质功能减退或亢进综合征患者进行了调查并给予住院治疗。根据疾病情况将患者分为5组。第一组为34例库欣综合征女性患者，第二组为10例库欣综合征男性患者，第三组为10例艾迪生病男性患者，第四组为6例雄激素性皮质醇增多症女性患者。在治疗前后，通过临床随访和综合激素检测对生殖系统的形态功能障碍进行跟踪。这些障碍的发生率非常高，临床观察结果和实验室数据表明，肾上腺皮质激素分泌过多和其循环水平降低均对生殖功能产生负面影响，或在妊娠情况下构成危险因素。通过肾上腺皮质的治疗性处理可实现对流产和/或不育的预防性治疗。
