German S V, Vinnitskiĭ L I
Lab Delo. 1990(4):36-40.
Blood serum trypsin was radioimmunoassayed in 46 patients with adrenocortical hyperfunction and in 24 ones with its hypofunction. The findings evidence that excess of endogenous adrenal steroids leads to elevation of radioimmune trypsin (RIT) concentration. The presence of chronic pancreatitis in hypercorticism did not essentially influence the value of the examined parameter, nor did the development of diabetes mellitus. Corticosteroid deficit in the body was not associated with changes in the blood serum RIT concentration. Systematic glucocorticoid therapy resulted in elevation of RIT level. The serum enzyme concentration was also increased in hypoadrenocorticism patients not administered glucocorticoids, suffering from concomitant chronic pancreatitis. Therefore the test was not informative for the diagnosis of chronic pancreatitis in the patients with the endogenous hyperadrenocorticism syndrome but may be helpful in the recognition of the condition in the patients with chronic adrenal insufficiency; interpretation of this test results in hypoadrenocorticism patients treated with glucocorticoids should be performed by efficient specialists.
对46例肾上腺皮质功能亢进患者和24例肾上腺皮质功能减退患者的血清胰蛋白酶进行了放射免疫测定。结果表明，内源性肾上腺类固醇过量会导致放射免疫胰蛋白酶（RIT）浓度升高。皮质醇增多症患者合并慢性胰腺炎，对所检测参数的值无实质性影响，糖尿病的发生也无影响。体内皮质类固醇缺乏与血清RIT浓度变化无关。系统性糖皮质激素治疗导致RIT水平升高。未接受糖皮质激素治疗、合并慢性胰腺炎的肾上腺皮质功能减退患者血清酶浓度也升高。因此，该检测对内源性肾上腺皮质功能亢进综合征患者慢性胰腺炎的诊断无信息价值，但可能有助于识别慢性肾上腺皮质功能不全患者的病情；对接受糖皮质激素治疗的肾上腺皮质功能减退患者的检测结果解释应由专业人员进行。
