通过饮食方法减少囊性纤维化患者胆汁酸的流失。
Reduction of bile acid loss in cystic fibrosis by dietary means.
作者信息
Smalley C A, Brown G A, Parkes M E, Tease H, Brookes V, Anderson C M
出版信息
Arch Dis Child. 1978 Jun;53(6):477-82. doi: 10.1136/adc.53.6.477.
On a 'normal' diet increased faecal bile acid excretion was found in 14 of 16 children with cystic fibrosis who had steatorrhoea, but excretion was normal in 2 such children without steatorrhoea. The 16 children with steatorrhoea took 3 regimens of diet and therapy: a 'normal' diet with pancreatic enzyme supplements, a diet of reduced long-chain triglycerides with added medium-chain triglycerides, and the same diet with added pancreatic enzyme supplements. On each of these three regimens steatorrhoea and faecal bile acid loss were significantly less than on no treatment, with the lowest excretions occurring on the diet of reduced long-chain triglycerides with added medium-chain triglycerides and pancreatic enzyme supplements. Although a reduction in steatorrhoea was nearly always accompanied by a decrease in bile acid excretion, the initial bile acid loss was very variable and could not be predicted for any given degree of steatorrhoea. This suggests that at least one other factor, possibly liver disease or bile acid pool size, influences bile acid loss in the faeces.
在“正常”饮食情况下，16名患有脂肪泻的囊性纤维化患儿中有14名粪便胆汁酸排泄增加，但2名无脂肪泻的此类患儿排泄正常。这16名患有脂肪泻的患儿采用了3种饮食和治疗方案：补充胰酶的“正常”饮食、减少长链甘油三酯并添加中链甘油三酯的饮食，以及添加胰酶补充剂的相同饮食。在这三种方案中的每一种方案下，脂肪泻和粪便胆汁酸流失均明显少于未治疗时，在减少长链甘油三酯并添加中链甘油三酯及胰酶补充剂的饮食中排泄量最低。尽管脂肪泻的减少几乎总是伴随着胆汁酸排泄的减少，但最初的胆汁酸流失差异很大，无法针对任何给定程度的脂肪泻进行预测。这表明至少还有一个其他因素，可能是肝脏疾病或胆汁酸池大小，会影响粪便中胆汁酸的流失。
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