哮喘儿童组胺激发试验的可重复性
Reproducibility of histamine challenge tests in asthmatic children.
作者信息
Hariparsad D, Wilson N, Dixon C, Silverman M
出版信息
Thorax. 1983 Apr;38(4):258-60. doi: 10.1136/thx.38.4.258.
Abstract
The measurement of bronchial reactivity by histamine challenge testing is of increasing clinical importance in paediatrics. By means of a simple tidal breathing technique for the measurement of histamine sensitivity (expressed as PC20--the concentration of histamine which produces a 20% fall in peak flow rate) in childhood asthma, the reproducibility of pairs of tests was estimated over one hour and 24-hour intervals in 22 children. Under carefully controlled conditions the 95% confidence limits of PC20 were 0.8-1.25 X baseline PC20 after one hour and 0.36-2.8 X baseline PC20 after 24 hours.
摘要
通过组胺激发试验测量支气管反应性在儿科临床中的重要性日益增加。采用一种简单的潮气呼吸技术测量儿童哮喘中组胺敏感性（以PC20表示，即导致峰值流速下降20%的组胺浓度），在22名儿童中估计了一小时和24小时间隔内成对测试的可重复性。在严格控制的条件下，PC20的95%置信区间在一小时后为基线PC20的0.8 - 1.25倍，24小时后为基线PC20的0.36 - 2.8倍。
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