喘息性婴儿的气道反应性：功能性β肾上腺素能受体的证据
Airway responsiveness in wheezy infants: evidence for functional beta adrenergic receptors.
作者信息
Prendiville A, Green S, Silverman M
机构信息
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
出版信息
Thorax. 1987 Feb;42(2):100-4. doi: 10.1136/thx.42.2.100.
The effect of nebulised salbutamol on the bronchial response to nebulised histamine was studied in five wheezy infants aged 3-12 months. The response to doubling concentrations of up to 8 g/l of histamine was assessed by the change in the maximum flow at FRC (VmaxFRC), measured by flow-volume curves produced during forced expiration with a pressure jacket. The concentration of histamine required to provoke a 30% fall in VmaxFRC (PC30) was measured. All of the infants responded to low concentrations of histamine during control tests before and after nebulised saline (mean PC30 1.07 and 0.51 g/l). On a separate day there was a similar response to histamine before salbutamol (PC30 0.57 g/l), but after salbutamol the response was completely abolished up to the maximum concentration of histamine in all subjects (PC30 greater than 8 g/l). Thus wheezy infants have highly effective beta 2 adrenoceptors in intrathoracic airways.
研究了雾化沙丁胺醇对5名3至12个月大喘息婴儿支气管对雾化组胺反应的影响。通过在压力衣辅助下用力呼气时产生的流量-容积曲线测量功能残气量（FRC）时的最大流量变化（VmaxFRC），评估对高达8 g/l组胺双倍浓度增加的反应。测量引起VmaxFRC下降30%（PC30）所需组胺的浓度。在雾化盐水前后的对照试验中，所有婴儿均对低浓度组胺有反应（平均PC30分别为1.07和0.51 g/l）。在另一天，在使用沙丁胺醇前对组胺有类似反应（PC30为0.57 g/l），但在使用沙丁胺醇后，所有受试者对组胺的反应在最高浓度时完全消失（PC30大于8 g/l）。因此，喘息婴儿胸腔内气道中有高效的β2肾上腺素能受体。
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