Griswold W R, McNeal R, Mendoza S A, Sellers B B, Higgins S
Arch Dis Child. 1978 Jul;53(7):594-6. doi: 10.1136/adc.53.7.594.
The antihypertensive effect of oral propranolol was studied in 9 children with hypertension. After treatment with propranolol, systolic blood pressure fell by an average of 26 mmHg (P less than 0.01). Diastolic pressure decreased by 20 mmHg on average (P less than 0.01). The mean propranolol dose was 2.5 mg/kg per day. Side effects included bradycardia and anorexia. There was no correlation between pretreatment plasma renin activity and fall in blood pressure. Propranolol is an effective and well tolerated antihypertensive agent in children.
对9名高血压儿童研究了口服普萘洛尔的降压效果。用普萘洛尔治疗后，收缩压平均下降26 mmHg（P<0.01）。舒张压平均下降20 mmHg（P<0.01）。普萘洛尔的平均剂量为每天2.5 mg/kg。副作用包括心动过缓和厌食。治疗前血浆肾素活性与血压下降之间无相关性。普萘洛尔是一种对儿童有效的、耐受性良好的降压药。
