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对双脒化合物（乙磺半胱氨酸戊烷脒）在印度北比哈尔邦出现的抗治疗性黑热病病例中的评估。

Evaluation of diamidine compound (pentamidine isethionate) in the treatment resistant cases of kala-azar occurring in North Bihar, India.

作者信息

Jha T K

出版信息

Trans R Soc Trop Med Hyg. 1983;77(2):167-70. doi: 10.1016/0035-9203(83)90058-5.

DOI:10.1016/0035-9203(83)90058-5
PMID:6868096
Abstract

Pentamidine isethionate was found to be a very effective therapeutic agent in the treatment of pentavalent antimonial-resistant cases of kala-azar. Cardiotoxicity and metabolic disturbance (diabetes mellitus-like state) were found to be limiting factors in the use of this drug. Frequent clinical, electrocardiographic and biochemical observations are required during and after course of treatment and pentamidine treatment should be restricted to in-patients in hospitals.

摘要

已发现乙磺半胱氨酸戊烷脒是治疗对五价锑耐药的黑热病病例的一种非常有效的治疗剂。心脏毒性和代谢紊乱（类糖尿病状态）被发现是使用该药物的限制因素。在治疗期间和治疗后需要频繁进行临床、心电图和生化观察，并且戊烷脒治疗应限于医院住院患者。

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1
Evaluation of diamidine compound (pentamidine isethionate) in the treatment resistant cases of kala-azar occurring in North Bihar, India.对双脒化合物（乙磺半胱氨酸戊烷脒）在印度北比哈尔邦出现的抗治疗性黑热病病例中的评估。
Trans R Soc Trop Med Hyg. 1983;77(2):167-70. doi: 10.1016/0035-9203(83)90058-5.
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Pentamidine-induced diabetes mellitus.喷他脒诱发的糖尿病
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Changing response to diamidine compounds in cases of kala-azar unresponsive to antimonial.
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Epidemiological, clinical and therapeutic features of Bihar kala-azar (including post kala-azar dermal leishmaniasis).比哈尔邦黑热病（包括黑热病后皮肤利什曼病）的流行病学、临床及治疗特征
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[A case of visceral leishmaniasis (Kala-Azar). Side effects during the treatment with pentamidine].[一例内脏利什曼病（黑热病）。喷他脒治疗期间的副作用]
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Treatment of visceral leishmaniasis in Bihar.比哈尔邦内脏利什曼病的治疗
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