Dumelin E E, Dillard C J, Tappel A L
Arch Environ Health. 1978 May-Jun;33(3):129-35. doi: 10.1080/00039896.1978.10667322.
Pentane and ethane, which arise during lipid peroxidation in vivo, were measured by gas chromatography in breath samples of rats fed for 8 weeks a vitamin E-deficient diet to which had been added 0, 11, or 40 IU vitamin E acetate per kg. Further lipid peroxidation was induced by exposure of individual rats to 1 ppm ozone for 60 min. Nonparametric statistical analysis of the data for pentane expired before exposure of rats to ozone gave alpha values (alpha = 2P) of 0.006 when the O vitamin E group was compared with either of the vitamin E-supplemented groups. For ethane, comparison of the O vitamin E group with the groups supplemented with 11 and 40 IU vitamin E/kg of diet were 0.0294 and 0.0080, respectively. Alpha values less than .05 were considered significant. After a 60-min exposure of rats to 1 ppm ozone, the paired t-test showed pentane to be significantly (P less than .005) increased in only the rats fed the vitamin E-deficient diet.
戊烷和乙烷是体内脂质过氧化过程中产生的物质，通过气相色谱法对喂食8周维生素E缺乏饮食（每千克添加了0、11或40国际单位维生素E醋酸酯）的大鼠呼出气体样本进行测定。通过将每只大鼠暴露于1 ppm臭氧中60分钟来诱导进一步的脂质过氧化。对大鼠暴露于臭氧之前呼出的戊烷数据进行非参数统计分析，当将维生素E缺乏组与任何一个补充维生素E的组进行比较时，α值（α = 2P）为0.006。对于乙烷，维生素E缺乏组与分别补充11和40国际单位维生素E/千克饮食的组的比较结果分别为0.0294和0.0080。α值小于0.05被认为具有显著性。在大鼠暴露于1 ppm臭氧60分钟后，配对t检验显示，仅在喂食维生素E缺乏饮食的大鼠中，戊烷显著增加（P小于0.005）。
