冷不溶性球蛋白的研究。I. 风湿性疾病中枸橼酸盐血浆中的浓度
Studies on cold insoluble globulin. I Concentrations in citrated plasma in rheumatic disorders.
作者信息
Fyrand O, Munthe E, Solum N O
出版信息
Ann Rheum Dis. 1978 Aug;37(4):347-50. doi: 10.1136/ard.37.4.347.
Abstract
Cold insoluble globulin (CIG) is a normal glycoprotein of human serum and plasma. The physiological significance of this protein is unknown, but is shows a temperature-dependent relation to fibrinogen and fibrin. It is possible that it represents a substrate for activated fibrin-stabilising factor in the polymerisation of fibrin. CIG is found on the surface of fibroblasts. In the present study CIG was estimated in citrated plasma in 115 patients with rheumatic diseases. Increased amounts were found in patients with systemic lupus erythematosus, secondary amyloidosis in classical and definite rheumatoid arthritis, and in male patients with juvenile rheumatoid arthritis.
摘要
冷不溶性球蛋白（CIG）是人体血清和血浆中的一种正常糖蛋白。这种蛋白质的生理意义尚不清楚，但它与纤维蛋白原和纤维蛋白呈现出温度依赖性关系。它有可能是纤维蛋白聚合过程中活化纤维蛋白稳定因子的一种底物。CIG存在于成纤维细胞表面。在本研究中，对115例风湿性疾病患者的枸橼酸盐血浆中的CIG进行了测定。在系统性红斑狼疮、经典型和明确型类风湿关节炎继发淀粉样变性患者以及青少年类风湿关节炎男性患者中发现其含量增加。
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Sequential changes of plasma proteins after surgical trauma.手术创伤后血浆蛋白的序列变化。
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