Eaker E D, Haynes S G, Feinleib M
Am J Epidemiol. 1983 Jul;118(1):23-41. doi: 10.1093/oxfordjournals.aje.a113614.
Analyses of spouse data from the Framingham Heart Study indicated that the risk of developing coronary heart disease among Type A men, compared with Type B men, was modified by the behavior or social status of their wives. Between 1965 and 1967, 269 spouse pairs, in which the husbands were 45-64 years of age, were administered an extensive psychosocial questionnaire. These pairs were followed over a 10-year period for the development of heart disease. When Type A and Type B men were stratified by the social and personality characteristics of their wives, it was found that the differential rate of heart disease between Type A and Type B men was present only in situations where the wives' characteristics might be deemed stressful. Type A husbands were 2.5 times as likely to develop coronary heart disease as Type B husbands if married to women with 13 or more years of education, and had 3.5 times the coronary risk of Type B husbands if married to a woman employed outside the home. When spouses were stratified by behavior type, employed outside the home. When spouses were stratified by behavior type, the highest rates of coronary heart disease were among Type A men married to Type B wives (25%). This rate was over three times the rate among Type B men married to Type B wives (7.8%). When tests for interaction between the behavior type of husbands and characteristics of wives were calculated, significant effects were found among blue-collar men on all variables except wives' educational level. This indicates that Type A men in white-collar occupations are at higher risk of heart disease regardless of wives' characteristics; whereas, the effect of behavior type among men in blue-collar occupations was interrelated with and modified by wives' characteristics. These results were apparent regardless of the husbands' standard coronary risk factors.
对弗雷明汉心脏研究中的配偶数据进行分析后发现，与B型男性相比，A型男性患冠心病的风险会因其妻子的行为或社会地位而有所改变。1965年至1967年期间，对269对丈夫年龄在45至64岁之间的配偶进行了广泛的心理社会问卷调查。对这些配偶进行了为期10年的跟踪，以观察心脏病的发病情况。当根据妻子的社会和性格特征对A型和B型男性进行分层时，发现只有在妻子的特征可能被认为具有压力的情况下，A型和B型男性之间心脏病的发病率差异才会出现。如果A型丈夫娶的是受过13年或以上教育的女性，那么他们患冠心病的可能性是B型丈夫的2.5倍；如果娶的是在外工作的女性，那么他们患冠心病的风险是B型丈夫的3.5倍。当根据行为类型对配偶进行分层时，冠心病发病率最高的是娶了B型妻子的A型男性（25%）。这一发病率是娶了B型妻子的B型男性发病率（7.8%）的三倍多。在计算丈夫的行为类型与妻子的特征之间的相互作用测试时，发现除了妻子的教育水平外，蓝领男性在所有变量上都有显著影响。这表明，无论妻子的特征如何，从事白领职业的A型男性患心脏病的风险更高；而蓝领职业男性的行为类型的影响与妻子的特征相互关联并受到其影响。无论丈夫的标准冠心病风险因素如何，这些结果都是明显的。
