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压力可导致冠心病的机制。

Mechanisms by which stress can lead to coronary heart disease.

作者信息

Henry J P

出版信息

Postgrad Med J. 1986 Jul;62(729):687-93. doi: 10.1136/pgmj.62.729.687.

DOI:10.1136/pgmj.62.729.687
PMID:3748938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2418752/
Abstract

Much stress is of psychological origin and due to emotional arousal. The mechanisms by which anger, helplessness, or a sense of control and serenity exert their various neuroendocrine effects are discussed. Primacy is given to three systems; to the catecholamines, to testosterone and to cortisol. Evidence that they interact to accelerate the arteriosclerotic process is cited. The protective aspects of intimacy are discussed together with evidence that certain personality types promote it in the marital situation while others do not. It is suggested that the post-traumatic stress syndrome may relate to the coronary-prone personality for it involves an alexithymic disturbance of the emotional competence required for successful intimacy.

摘要

许多压力源于心理因素和情绪唤起。本文讨论了愤怒、无助感或控制感与平静感产生各种神经内分泌效应的机制。重点关注三个系统:儿茶酚胺、睾酮和皮质醇。文中引用了它们相互作用加速动脉硬化进程的证据。探讨了亲密关系的保护作用,以及某些人格类型在婚姻关系中促进亲密关系而其他人格类型则不然的证据。研究表明,创伤后应激障碍可能与易患冠心病的人格有关,因为它涉及成功建立亲密关系所需的情感能力的述情障碍。

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本文引用的文献

1
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2
Testosterone, status, and mood in human males.
Horm Behav. 1980 Sep;14(3):236-46. doi: 10.1016/0018-506x(80)90032-x.
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Hemispheric asymmetry in the expression of positive and negative emotions. Neurologic evidence.
Arch Neurol. 1982 Apr;39(4):210-8. doi: 10.1001/archneur.1982.00510160016003.
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Spouse behavior and coronary heart disease in men: prospective results from the Framingham heart study. II. Modification of risk in type A husbands according to the social and psychological status of their wives.男性配偶行为与冠心病:弗雷明汉心脏研究的前瞻性结果。II. 根据A型丈夫妻子的社会和心理状况对风险的修正
Am J Epidemiol. 1983 Jul;118(1):23-41. doi: 10.1093/oxfordjournals.aje.a113614.
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Stress down-regulates corticosterone receptors in a site-specific manner in the brain.压力以位点特异性方式下调大脑中的皮质酮受体。
Endocrinology. 1984 Jan;114(1):287-92. doi: 10.1210/endo-114-1-287.
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Social instability and coronary artery atherosclerosis in cynomolgus monkeys.食蟹猴的社会不稳定与冠状动脉粥样硬化
Neurosci Biobehav Rev. 1983 Winter;7(4):485-91. doi: 10.1016/0149-7634(83)90028-3.
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Alexithymia: concept, measurement, and implications for treatment.述情障碍:概念、测量及其对治疗的意义。
Am J Psychiatry. 1984 Jun;141(6):725-32. doi: 10.1176/ajp.141.6.725.
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Soc Sci Med. 1982;16(4):369-80. doi: 10.1016/0277-9536(82)90047-8.
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