过敏的非特异性增强作用。I. 百日咳博德特氏菌疫苗对IgE合成的体内效应
The non-specific enhancement of allergy. I. In vivo effects of Bordetella pertussis vaccine on IgE synthesis.
作者信息
Pauwels R, Van der Straeten M, Platteau B, Bazin H
出版信息
Allergy. 1983 May;38(4):239-46. doi: 10.1111/j.1398-9995.1983.tb01617.x.
Bordetella pertussis organisms, with or without a small dose of alumhydroxide, enhance in rats the production of IgE antibodies to an unrelated antigen, even if this antigen has been administered 6 weeks beforehand. This non-specific enhancement of IgE antibodies is accompanied by a substantial rise in total serum IgE and by the production of IgE antibodies to B. pertussis. The effect of B. pertussis on IgE synthesis is dose-dependent. No effect of B. pertussis on IgE production can be observed in nude rats.
百日咳博德特氏菌，无论是否添加小剂量氢氧化铝，均可增强大鼠针对无关抗原的IgE抗体生成，即便该抗原在六周前就已接种。IgE抗体的这种非特异性增强伴随着血清总IgE显著升高以及针对百日咳博德特氏菌的IgE抗体生成。百日咳博德特氏菌对IgE合成的影响呈剂量依赖性。在裸鼠中未观察到百日咳博德特氏菌对IgE生成有影响。
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