Ogg T W, MacDonald I A, Beechey A P, Morrison C G
Anaesthesia. 1983 Jun;38(6):534-9.
Sixty patients undergoing day-case dental surgery were either given sublingual buprenorphine 0.2 mg or 0.4 mg or a buffered placebo 1 hour prior to general anaesthesia. Pre-operative anxiety was not allayed and there was no significant analgesia afforded by buprenorphine in the immediate postoperative period. The synthetic opiate depressed psychomotor function and both 0.2 mg and 0.4 mg buprenorphine yielded a significantly higher incidence of postoperative nausea and vomiting.
60例行日间牙科手术的患者在全身麻醉前1小时分别给予0.2毫克或0.4毫克舌下含服丁丙诺啡或一种缓冲安慰剂。术前焦虑并未减轻,丁丙诺啡在术后即刻也未提供显著的镇痛效果。这种合成阿片类药物会抑制精神运动功能,0.2毫克和0.4毫克丁丙诺啡术后恶心和呕吐的发生率均显著更高。