Bradley E L, Hall J R, Lutz J, Hamner L, Lattouf O
Ann Surg. 1983 Aug;198(2):130-3. doi: 10.1097/00000658-198308000-00002.
Fifteen patients with severe pancreatitis underwent cardiovascular monitoring in an intensive care unit. The principal findings were a high cardiac index and a decrease in systemic vascular resistance. A significant negative correlation was found to exist between these two parameters (p less than 0.001). Severe pancreatitis apparently results in hemodynamic changes similar to those observed in sepsis. The mechanisms responsible for these observations are not known, although circulating vasoactive compounds resulting from pancreatic necrosis remain a strong possibility. Despite demonstrating a significant decrease in left ventricular stroke work index and an abnormal elevation in pulmonary capillary wedge pressure, the existence of a myocardial depressant factor could not be conclusively proved from these data.
15例重症胰腺炎患者在重症监护病房接受了心血管监测。主要发现为心脏指数升高和全身血管阻力降低。发现这两个参数之间存在显著的负相关（p小于0.001）。重症胰腺炎显然会导致与脓毒症中观察到的类似的血流动力学变化。尽管胰腺坏死产生的循环血管活性化合物仍是一种很大的可能性，但导致这些观察结果的机制尚不清楚。尽管左心室每搏功指数显著降低且肺毛细血管楔压异常升高，但从这些数据中无法确凿地证明心肌抑制因子的存在。
