Shakhlamov V A, Barkhina T G, Eshmirzaev M E
Arkh Anat Gistol Embriol. 1983 Apr;84(4):53-61.
Ultrastructural changes in adenylate cyclase activity in the columnar and goblet cells of the rat colon were studied 10, 30 min and 1, 4, 6, 12 and 24 h following injection of cholera toxin (choleragen) into the small intestine of 60 animals. The toxin rather quickly (within 30 min) reached the colon and stimulated membrane-bound adenylate cyclase activity in the colonic columnar and goblet cells. Ultrastructural alterations in the columnar cells, which were comparable to those previously described in choleragen-treated small intestine but were considerably less pronounced, could be detected 1-12 h following the toxin injection. In the colon, stimulation of mucus production by the goblet cells was much more pronounced than in the small intestine. The data obtained suggest that colon is succeptible to the action of choleragen but they cannot be interpreted as an indication of its disturbed re-absorptive capacity.
在60只动物的小肠注射霍乱毒素（霍乱原）后10分钟、30分钟以及1小时、4小时、6小时、12小时和24小时，研究了大鼠结肠柱状细胞和杯状细胞中腺苷酸环化酶活性的超微结构变化。毒素相当迅速（在30分钟内）到达结肠，并刺激结肠柱状细胞和杯状细胞膜结合的腺苷酸环化酶活性。在毒素注射后1 - 12小时可检测到柱状细胞的超微结构改变，这些改变与先前在霍乱原处理的小肠中描述的改变相似，但程度要轻得多。在结肠中，杯状细胞对黏液产生的刺激比在小肠中更为明显。所获得的数据表明结肠易受霍乱原的作用，但这些数据不能被解释为其重吸收能力受到干扰的迹象。
