Aisen M L, Bacon B R, Goodman A M, Chester E M
Arch Ophthalmol. 1983 Jul;101(7):1049-52. doi: 10.1001/archopht.1983.01040020051008.
The incidence of clinically apparent retinal changes in 35 anemic patients and 35 age- and sex-matched control subjects was studied. Retinal photographs of all subjects were obtained. From these, all vascular and extravascular retinal lesions were noted. No retinal abnormalities were observed in the control subjects. Seven (20%) of the anemic patients exhibited extravascular lesions. There was no relationship detected between the occurrence of these changes and the severity or the cause of the anemia. Employing the assumption that true venous length for a given net distance traveled correlates with the degree of venous tortuosity, venous length over a standard radial distance from the optic disc was assessed with a curvometer. A significant negative correlation was determined between venous length and the level of hematocrit, thereby implying that retinal venous tortuosity is directly related to severity of anemia.
对35名贫血患者以及35名年龄和性别相匹配的对照受试者进行了临床明显视网膜变化发生率的研究。获取了所有受试者的视网膜照片。从中记录了所有视网膜血管性和血管外性病变。对照受试者未观察到视网膜异常。7名（20%）贫血患者出现血管外病变。这些变化的发生与贫血的严重程度或病因之间未发现相关性。基于给定净行程的真实静脉长度与静脉迂曲程度相关的假设，用曲率计评估了从视盘起标准径向距离上的静脉长度。确定静脉长度与血细胞比容水平之间存在显著负相关，从而表明视网膜静脉迂曲与贫血严重程度直接相关。
