Carpenter S L, Sevoian M
Avian Dis. 1983 Apr-Jun;27(2):344-56.
The immune response of chickens to Listeria monocytogenes was studied as a potential model for cell-mediated immunocompetence. Chickens genetically resistant and susceptible to Marek's disease (MD) did not differ in their ability to survive Listeria, although during the early stages of infection the bacteria replicated more readily in MD-susceptible chickens. MD-susceptible chickens responded earlier than MD-resistant chickens, and with equal or increased intensity, in assays of various components of the cell-mediated reaction. These assays included T-cell activation, delayed-type hypersensitivity, and macrophage activation. These data indicate that genetic resistance or susceptibility to MD is not wholly dependent on the innate immunocompetence of the host. Co-infection with Listeria was used to measure cellular immunocompetence in MD-infected chickens. MD virus had no effect on the ability of host macrophages to control the growth of Listeria. The cell-mediated response was suppressed in MD-susceptible chickens. The occurrence of spleen cell proliferation, followed by marked suppression of the effector arm of the immune response in susceptible but not resistant chickens, indicated the possibility of an active suppressor-cell population associated with genetic susceptibility to MD.
研究了鸡对单核细胞增生李斯特菌的免疫反应，将其作为细胞介导免疫能力的潜在模型。对马立克氏病（MD）具有遗传抗性和易感性的鸡在抵抗李斯特菌的能力上没有差异，尽管在感染早期，细菌在MD易感鸡中更容易繁殖。在细胞介导反应的各种成分检测中，MD易感鸡比MD抗性鸡反应更早，且强度相同或更高。这些检测包括T细胞活化、迟发型超敏反应和巨噬细胞活化。这些数据表明，对MD的遗传抗性或易感性并不完全取决于宿主的先天免疫能力。用李斯特菌共同感染来测量MD感染鸡的细胞免疫能力。MD病毒对宿主巨噬细胞控制李斯特菌生长的能力没有影响。MD易感鸡的细胞介导反应受到抑制。脾脏细胞增殖的出现，随后在易感但非抗性鸡中免疫反应的效应臂受到明显抑制，表明可能存在与MD遗传易感性相关的活跃抑制细胞群体。
