Ghidoni R, Sonnino S, Chigorno V, Venerando B, Tettamanti G
Biochem J. 1983 Mar 1;209(3):885-8. doi: 10.1042/bj2090885.
The ganglioside patterns in the liver of different inbred and hybrid strains of mice were investigated. The inbred strains were Balb/cAnNCr1BR, C57BL/6NCr1BR, DBA/2NCr1BR. C3H/HeNCr1BR; the hybrid strain was the Swiss albino. The following major gangliosides were found to be present in mouse liver: GM3-NeuAc; GM3-NeuGl, GM2 [a mixture of one species carrying N-acetylneuraminic acid (NeuAc) and one carrying N-glycollylneuraminic acid (NeuGl)], GM1 and GD1a-(NeuAc,NeuGl). The qualitative and quantitative patterns of liver gangliosides were markedly different in the various inbred strains of mice; in Balb/cAnNCr1BR strain, ganglioside GM2 was preponderant (99.2% of total ganglioside content); in C57BL/6NCr1BR, the major ganglioside was GM2 (90.4%), followed by GM3-NeuAc (5.6%) and GM3-NeuGl (4.0%); in DBA/2NCr1BR, GM2 accounted for 77.1%, GD1a-(NeuAc,NeuGl) 18.9% and GM1 3.1% of gangliosides; in C3H/HeNCr1BR, GM2 constituted 50.6%, GM1 22.8% and GD1a-(NeuAc,NeuGl) 22.1%. In the hybrid Swiss albino mice, liver ganglioside composition markedly varied from one animal to another, GM3-NeuGl, GM2 and GD1a-(NeuAc,NeuGl) being the predominant gangliosides in the various cases.
对不同近交系和杂交系小鼠肝脏中的神经节苷脂模式进行了研究。近交系包括Balb/cAnNCr1BR、C57BL/6NCr1BR、DBA/2NCr1BR、C3H/HeNCr1BR；杂交系为瑞士白化小鼠。发现小鼠肝脏中存在以下主要神经节苷脂：GM3 - 唾液酸（NeuAc）；GM3 - 神经氨酸（NeuGl），GM2[一种携带N - 乙酰神经氨酸（NeuAc）和一种携带N - 羟乙酰神经氨酸（NeuGl）的混合物]，GM1和GD1a - （NeuAc，NeuGl）。不同近交系小鼠肝脏神经节苷脂的定性和定量模式明显不同；在Balb/cAnNCr1BR品系中，神经节苷脂GM2占优势（占总神经节苷脂含量的99.2%）；在C57BL/6NCr1BR中，主要神经节苷脂是GM2（90.4%），其次是GM3 - 唾液酸（NeuAc，5.6%）和GM3 - 神经氨酸（NeuGl，4.0%）；在DBA/2NCr1BR中，GM2占神经节苷脂的77.1%，GD1a - （NeuAc，NeuGl）占18.9%，GM1占3.1%；在C3H/HeNCr1BR中，GM2占50.6%，GM1占22.8%，GD1a - （NeuAc，NeuGl）占22.1%。在杂交的瑞士白化小鼠中，肝脏神经节苷脂组成在不同动物之间明显不同，GM3 - 神经氨酸（NeuGl）、GM2和GD1a - （NeuAc，NeuGl）在不同情况下是主要的神经节苷脂。
