一株假单胞菌对脱氧胆酸的降解。具有A环不饱和的酸性中间体。
Deoxycholic acid degradation by a Pseudomonas sp. Acidic intermediates with A-ring unsaturation.
作者信息
Leppik R A
出版信息
Biochem J. 1983 Mar 15;210(3):829-36. doi: 10.1042/bj2100829.
Abstract
The microbial catabolism of deoxycholic acid by a Pseudomonas sp. was studied, and six further acidic intermediates were isolated, as their methyl esters. Evidence is presented that the compounds are methyl 12 alpha-hydroxy-3-oxochol-4-en-24-oate, methyl 12 alpha-hydroxy-3-oxo-23,24-dinorchol-4-en-22-oate, methyl 12 alpha-hydroxy-3-oxochola-1,4-dien-24-oate, methyl 12 alpha-hydroxy-3-oxo-23,24-dinorchola-1,4-dien-22-oate, methyl 12 alpha-hydroxy-3-oxochola-1,4,22E-trien-24-oate and methyl 12 alpha-hydroxy-3-oxo-23,24-dinorchola-1,4,17(20)-trien-22-oate. On the basis of these compounds, together with the seven intermediates previously reported, a catabolic pathway is proposed.
摘要
对一种假单胞菌属细菌对脱氧胆酸的微生物分解代谢进行了研究，并分离出了另外六种酸性中间体，以甲酯形式存在。有证据表明这些化合物分别是12α-羟基-3-氧代胆-4-烯-24-酸甲酯、12α-羟基-3-氧代-23,24-二降胆-4-烯-22-酸甲酯、12α-羟基-3-氧代胆-1,4-二烯-24-酸甲酯、12α-羟基-3-氧代-23,24-二降胆-1,4-二烯-22-酸甲酯、12α-羟基-3-氧代胆-1,4,22E-三烯-24-酸甲酯和12α-羟基-3-氧代-23,24-二降胆-1,4,17(20)-三烯-22-酸甲酯。基于这些化合物，再结合之前报道的七种中间体，提出了一条分解代谢途径。
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