一种假单胞菌对脱氧胆酸的降解。分解代谢途径起始部分的酸性中间体。
Deoxycholic acid degradation by a Pseudomonas species. Acidic intermediates from the initial part of the catabolic pathway.
作者信息
Leppik R A
出版信息
Biochem J. 1982 Mar 15;202(3):747-51. doi: 10.1042/bj2020747.
Abstract
The microbial catabolism of deoxycholic acid by a Pseudomonas species was studied, and three acidic products were isolated as their methyl esters. Evidence is presented that the compounds are methyl 3 alpha,12 alpha-dihydroxy-23,24-dinor-5 beta-cholan-22-oate, methyl 12 alpha-hydroxy-3-oxo-5 beta-cholan-24-oate and methyl 12 alpha-hydroxy-3-oxo-23,24-dinor-5 beta-cholan-22-oate.
摘要
研究了一种假单胞菌属细菌对脱氧胆酸的微生物分解代谢，并分离出三种酸性产物作为它们的甲酯。有证据表明这些化合物分别是3α,12α-二羟基-23,24-二降-5β-胆烷-22-酸甲酯、12α-羟基-3-氧代-5β-胆烷-24-酸甲酯和12α-羟基-3-氧代-23,24-二降-5β-胆烷-22-酸甲酯。
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New dehydroxylation reaction observed in the microbiological degradation pathway of cholic acid.在胆酸的微生物降解途径中观察到新的脱羟基反应。
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Biochem Soc Trans. 1977;5(6):1711-3. doi: 10.1042/bst0051711.
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