Ariyan S, Enriquez R, Krizek T J
Arch Surg. 1978 Sep;113(9):1034-46. doi: 10.1001/archsurg.1978.01370210016002.
A most important contribution to the understanding of wound healing has been the identification of the myofibroblast. These cells contract like smooth muscle cells and have been identified in a variety of chronic and open wounds. The myofibroblasts have been reported as the causative factor resulting in the wound contraction. This report demonstrates the presence of the myofibroblasts in breast capsule contraction, as well as in Peyronie's disease. The presence of the myofibroblast in Peyronie's disease and Dupuytren's contracture suggests that the myofibroblast may be the causal factor behind the association of these two disorders. The evidence suggests that a spectrum of fibrocontractive disorders exists that has the myofibroblast as the common denominator. Some evidence is presented that permits the speculation that the myofibroblast may be a transformation of the local fibroblast to a smooth muscle cell in response to forces applied to the tissue.
对伤口愈合理解的一项极其重要的贡献是肌成纤维细胞的发现。这些细胞像平滑肌细胞一样收缩，并且已在多种慢性和开放性伤口中被识别出来。据报道，肌成纤维细胞是导致伤口收缩的致病因素。本报告证明了肌成纤维细胞在乳腺包膜挛缩以及佩罗尼氏病中的存在。佩罗尼氏病和掌腱膜挛缩症中肌成纤维细胞的存在表明，肌成纤维细胞可能是这两种病症关联背后的致病因素。有证据表明存在一系列以肌成纤维细胞为共同特征的纤维收缩性疾病。还提供了一些证据，据此推测肌成纤维细胞可能是局部成纤维细胞因施加于组织的力而向平滑肌细胞转化的结果。
