用右旋苯丙胺治疗的注意缺陷障碍伴多动男孩的尿中3-甲氧基-4-羟基苯乙二醇（MHPG）和高香草酸（HVA）排泄情况

Urinary MHPG and HVA excretion in boys with attention deficit disorder and hyperactivity treated with d-amphetamine.

作者信息

Shekim W O, Javaid J, Davis J M, Bylund D B

出版信息

Biol Psychiatry. 1983 Jun;18(6):707-14.

Abstract

The authors examined the excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in nine hyperactive and nine control boys admitted to a clinical research center. The hyperactives excreted lower 24 hr MHPG and HVA levels than controls. d-Amphetamine 0.5 mg/kg body weight daily for 2 weeks decreased MHPG and increased HVA. These data replicate the authors' previous findings on MHPG and HVA and on the effect of d-amphetamine in hyperactive children. The data suggest the involvement of norepinephrine and dopamine in the etiology of hyperactivity. It further suggests d-amphetamine may achieve its clinical effects in hyperactivity by inhibiting NE and potentiating DA activity.

摘要

作者对入住临床研究中心的9名多动男孩和9名对照男孩的3-甲氧基-4-羟基苯乙二醇（MHPG）和高香草酸（HVA）排泄情况进行了检查。多动男孩24小时的MHPG和HVA排泄水平低于对照组。每日按0.5毫克/千克体重给予右旋苯丙胺，持续2周，可使MHPG降低，HVA升高。这些数据重复了作者之前关于MHPG和HVA以及右旋苯丙胺对多动儿童影响的研究结果。数据表明去甲肾上腺素和多巴胺参与了多动的病因。这进一步表明右旋苯丙胺可能通过抑制去甲肾上腺素和增强多巴胺活性来实现其对多动的临床疗效。