Shekim W O, Dekirmenjian H, Chapel J L
Am J Psychiatry. 1977 Nov;134(11):1276-9. doi: 10.1176/ajp.134.11.1276.
The authors studied the excretion of 3-methoxy-4-hydroxyphenyl glycol (MHPG), normetanephrine (NM), metanephrine, and homovanillic acid in 7 hyperactive and 12 control children. MHPG was lower but NM was significantly higher in hyperactive children than in controls. Administration of d-amphetamine for 2 weeks depressed the levels of MHPG, NM, and metanephrine. The authors suggest a decreased central norepinephrine activity, which may be secondary to the interruption of norepinephrine fibers in the medial forebrain bundle.
作者研究了7名多动儿童和12名对照儿童体内3-甲氧基-4-羟基苯乙二醇（MHPG）、去甲变肾上腺素（NM）、变肾上腺素和高香草酸的排泄情况。多动儿童的MHPG水平较低，但NM水平显著高于对照组。给予右旋苯丙胺2周可降低MHPG、NM和变肾上腺素的水平。作者认为中枢去甲肾上腺素活性降低，这可能继发于中脑前束中去甲肾上腺素纤维的中断。
