右旋苯丙胺对多动男孩尿中多巴胺和去甲肾上腺素代谢产物的影响。

Effects of d-amphetamine on urinary metabolites of dopamine and norepinephrine in hyperactive boys.

作者信息

Shekim W O, Javaid J, Dekirmenjian H, Chapel J L, Davis J M

出版信息

Am J Psychiatry. 1982 Apr;139(4):485-8. doi: 10.1176/ajp.139.4.485.

DOI:10.1176/ajp.139.4.485

Abstract

The authors measured the urinary metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in 21 hyperactive boys and 12 matched healthy boys. The hyperactive boys excreted lower amounts of MHPG than control boys. Hyperactive drug responders excreted lower amounts of HVA than control boys and hyperactive nonresponders. Drug responders with normal MHPG excreted low amounts of HVA and those with normal HVA excreted low amounts of MHPG. d-Amphetamine decreased MHPG in all drug responders and HVA in drug responders with normal HVA levels, although it tended to increase HVA in those with low HVA levels. The authors discuss their data in terms of the possible involvement of norepinephrine and dopamine in the etiology of hyperactivity in children.

摘要

作者对21名多动男孩和12名匹配的健康男孩的尿液代谢物3-甲氧基-4-羟基苯乙二醇（MHPG）和高香草酸（HVA）进行了测量。多动男孩排出的MHPG量低于对照组男孩。多动药物反应者排出的HVA量低于对照组男孩和多动无反应者。MHPG正常的药物反应者排出的HVA量低，而HVA正常的药物反应者排出的MHPG量低。右旋苯丙胺使所有药物反应者的MHPG降低，使HVA水平正常的药物反应者的HVA降低，尽管它倾向于使HVA水平低的人HVA升高。作者根据去甲肾上腺素和多巴胺可能参与儿童多动病因的情况讨论了他们的数据。