Shen Y C, Wang Y F
Biol Psychiatry. 1984 Jun;19(6):861-70.
Although many authors have studied the urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) of minimal brain dysfunction (MBD) children to explore a possible mechanism for this disorder, the mechanism remains unclear. The present study extends the determinations of urinary MHPG X SO4 in MBD schoolchildren to a larger sample to determine whether or not the function of central norepinephrine (NE) of MBD children is normal. 24-hr urinary excretion of MHPG X SO4 was determined in 73 schoolchildren with MBD and 57 normal controls. MGPG X SO4 level was significantly lower in the MBD children than in the control group. 38 of these children received an open trial of methylphenidate and the urine specimen was examined blindly. The children with marked improvement showed significant decrease in urinary MHPD X SO4 while the nonresponders showed no change, but rather a slight increase. This was also demonstrated in a second drug trial in which eight MBD children received Chinese herbal medicine. The authors compare the clinical data with the biochemical findings and point out that the MBD children developed hypoactivity of central NE, especially those with positive genetic factors in their family history.
尽管许多作者研究了患有轻微脑功能障碍（MBD）的儿童尿中3-甲氧基-4-羟基苯乙二醇（MHPG）的排泄情况，以探寻这种病症的可能机制，但该机制仍不清楚。本研究将对患有MBD的学童尿中MHPG×SO4的测定扩展至更大样本，以确定患有MBD的儿童中枢去甲肾上腺素（NE）功能是否正常。对73名患有MBD的学童和57名正常对照者测定了24小时尿中MHPG×SO4的排泄量。患有MBD的儿童的MGPG×SO4水平显著低于对照组。其中38名儿童接受了哌甲酯的开放试验，并对尿样进行了盲检。症状明显改善的儿童尿中MHPD×SO4显著降低，而无反应者则无变化，反而略有升高。在第二项药物试验中也得到了证实，8名患有MBD的儿童接受了中药治疗。作者将临床数据与生化结果进行了比较，并指出患有MBD的儿童中枢NE活性降低，尤其是那些家族史中有阳性遗传因素的儿童。
