Nitter-Hauge S, Semb B, Abdelnoor M, Hall K V
Circulation. 1983 Sep;68(3 Pt 2):II169-74.
Throughout the period from 1977 to 1982, 426 patients underwent aortic valve replacement, 106 patients underwent mitral valve replacement, and 56 patients had double valve replacement with the Medtronic-Hall (previous Hall-Kaster) valve. Early and late mortality was 4% and 9% in the aortic group, 8% and 11% in the mitral group, and 7% and 13% in the double valve group. There was an 81% probability of surviving 5 years after aortic or double valve replacement, and a 75% probability of surviving 5 years after mitral valve replacement. Postoperative follow-up studies revealed low pressure gradients across the aortic as well as across the mitral valve prosthesis, irrespective of valve size. Exercise studies indicated good tolerance of increasing cardiac output during strenuous exercise tests in patients with aortic valve prosthesis. Thromboembolic complications in the aortic series included two cases of valve thrombosis and 11 thromboembolic episodes in 10 patients. In the mitral series an aspergillus thrombus was found on the valve at autopsy in a patient dying from multiple cerebral aspergillus abscesses, and five thromboembolic episodes occurred in four additional patients in the mitral series. In the double valve series there was one valve thrombosis and one patient had a thromboembolic episode.
在1977年至1982年期间，426例患者接受了主动脉瓣置换术，106例患者接受了二尖瓣置换术，56例患者使用美敦力 - 霍尔（原霍尔 - 卡斯特）瓣膜进行了双瓣膜置换术。主动脉瓣置换组的早期和晚期死亡率分别为4%和9%，二尖瓣置换组为8%和11%，双瓣膜置换组为7%和13%。主动脉瓣或双瓣膜置换术后5年存活的概率为81%，二尖瓣置换术后5年存活的概率为75%。术后随访研究显示，无论瓣膜大小，主动脉瓣和二尖瓣人工瓣膜上的压力梯度均较低。运动研究表明，主动脉瓣人工瓣膜患者在剧烈运动试验中对心输出量增加具有良好的耐受性。主动脉瓣置换系列中的血栓栓塞并发症包括2例瓣膜血栓形成和10例患者发生的11次血栓栓塞事件。在二尖瓣置换系列中，一名死于多发性脑曲霉菌脓肿的患者尸检时在瓣膜上发现了曲霉菌血栓，二尖瓣置换系列中的另外4名患者发生了5次血栓栓塞事件。在双瓣膜置换系列中，有1例瓣膜血栓形成，1例患者发生了血栓栓塞事件。
